Visual Snow 400 Case Summary Paper (which drug was effective for VS?)

“Visual Snow 400 Case Cleanup Paper Review”

It’s been a long time since I’ve prepared something about Visual Snow.

I’ve explained several times in the previous video about Visual Snow, right?

If you haven’t seen it, please click here.

The concept of visual snow has already been over 20 years, but much has not been revealed yet. That’s why there is no clear treatment.

For this reason, even if I read various papers, there are not many papers that can review for you

It’s a little vague to say that it’s something new that can directly help patients.

Nevertheless, I think many people want to know more about Visual snow, so I’d like to review the paper a little more often in the future.

the video about the professional content will be simplify in the future with lecture type editing

Just like a presentation..

If you want to see the content on video, you can watch it through my YouTube channel below.


paper introduction

Visual Snow 400 Case Summary Paper (which drug was effective for VS?)

Now, this is the paper I prepared today..

This paper was published in October 2021~ It was published in the British Journal BMJ open.

It’s not a very public journal, but it’s worth watching~ the title is

“A therapeutic response to 400 visual snow patients and the degree of progression of symptomswill be assessed.”


Research purpose

Visual Snow 400 Case Summary Paper (which drug was effective for VS?)

There isn’t much data organized because there is no concept or treatment for Visual Snow syndrome.

So the authors of this paper wanted to collect as many cases as possible and organize them. And study about it.

What types of drugs have positive or negative effects on Visual Snow Syndrome?

There was a change in the degree of symptoms over time.

About whether there have been symptoms change due to the surrounding environment, especially illuminance environments such as indoor and outdoors.


study design

Visual Snow 400 Case Summary Paper (which drug was effective for VS?)

Let’s see about study design? This study was conducted based on an Internet survey.

They promoted the research and gathered participants through a website called Eye on vision.

Only people who meet the Visual Snow diagnostic criteria were participated,

asked them to evaluate the effectiveness of the medication they used.

And they were asked to writing a visual snow symptom diary like this for 30 days.

Lastly, authors evaluated the level of symptoms according to the environment~ Outdoor sunny days, cloudy days, rainy days, soft lighting indoors, and fluorescent lamps in this way.


result

Visual Snow 400 Case Summary Paper (which drug was effective for VS?)

Let,s see the characteristics of the patients involved in the study,

First of all, there were 400 patients involved in the study.

The average age was 31 years , which was relatively young.

The average age of the onset of symptom patients remember was about 14 years old.

Effectiveness of drug

Visual Snow 400 Case Summary Paper (which drug was effective for VS?)

The following is an effectiveness of the drugs used by participants.

The effect is indicated by color.

Green if it is worse after drug use, purple if there was a effect, and blue if it had no effect.

I’ll explain it in detail from behind, but let me point it out briefly,

Antidepressants are the most commonly used drugs (red arrows),

And (blue arrows) these two drugs have a slightly different ratio of green-to-purple, which have effect rather than side effects.

It is a sedative called benzodiazepines and vitamins

Visual Snow 400 Case Summary Paper (which drug was effective for VS?)

Comparative analysis table for all medications used.. It’s so hard to see a table like this at paper.. Shall we just look at important things together?

Antidepressant

Visual Snow 400 Case Summary Paper (which drug was effective for VS?)

Did the antidepressant most used in Visual Snow patients really work?

A total of 227 people had experience using antidepressants.

Among them , only 15% of 35 cases were effective .

However, it should be noticed that there were more cases where symptoms worsened after taking antidepressants were 58(26%). And worsed cases were more than worked…

If so, is there any reason to use antidepressants in Visual Snow?

Alcohol and drugs

Visual Snow 400 Case Summary Paper (which drug was effective for VS?)

Next, it’s not a prescribed drug, but it’s alcohol and drugs that were investigated because it became a deteriorating factors.

Drugs… It’s not uncommon in Korea, but it seems to be used frequently in foreign countries because of accessibility;

Anyway, if you look at alcohol,

Symptoms can be seen worsened in 81% of cases.

If you have visual snow, you must avoid alcohol, right?

Vitamins and supplements

Visual Snow 400 Case Summary Paper (which drug was effective for VS?)

Next, it’s vitamins and supplementsthat were unexpected results.

Total 168 peoples has been tried it,

Only 26 of them, 15% of them worked. Is it meaningful to take it if you look at it this far?

But it was only 8, 5% who have side effect after taking vitamins. So vitamin shows very little side effect than other medicines.

I don’t know if this is… a placebo, but anyway

The probability of working is very low, but the risk of side effects is very low, so it’s worth a try.

But it’s not in the paper what kind of vitamin it is, huh?

Benzodiazepine

Visual Snow 400 Case Summary Paper (which drug was effective for VS?)

The following are benzodiazepines family of drugscommonly known as neurostable agents.

A total of 124 patients had experience taking it.

Of those, 38, 31% are effective.

23 people, 19% experienced side effects of getting worse symptoms.

I think we can consider it carefully if it’s a benefit and a risk ratio.


Medication effects depending on age

Visual Snow 400 Case Summary Paper (which drug was effective for VS?)

Here’s a comparison of how responsive the drug is, depending on age, gender, and more.

Among them, the only statistically significant factor was the age at which visual snow symptoms began~

In other words, the later the symptoms began, the more reactions to the drug.

But the caution here is to refer to all reactions, including negative reactions.

The later symptoms started, the better the response to the drug, whether positive or negative.


Symptom changes over the period

Visual Snow 400 Case Summary Paper (which drug was effective for VS?)

Here is an analysis of a 30-day symptom diary.

They scored the density, moving speed, color, size, etc. of noise.

And they compared the scores between days 1 and 10, days 11-20, and days 21 to 30.

There was no significant difference between them

We could know that visual snow symptoms were almost constant every day.


Change of symptoms according to the environment

Visual Snow 400 Case Summary Paper (which drug was effective for VS?)

Finally, it’s the changes of symptoms according to the environment. If you look to the left

(Red box) Sunny day in outdoor environment, cloudy day, rainy day

(Blue Box)Indoor Interior Lighting, Fluorescent Lighting

(green box) outdoors, they did an investigation by dividing it like this.

This is the score, the lower the score, the worse the symptoms.

If you look at it, you can notice that the outdoors have a higher score overall than the interior. The interior talking here is

It refers to interior lighting or white fluorescent lamps from one light source..

Of course, the worst environment is 1 point in the dark outdoors…


Summary

Visual Snow 400 Case Summary Paper (which drug was effective for VS?)

This is a summary of the paper

Most of the drugs used in Visual Snow didn’t work.

It would be better not to use it, especially in the case of atypical antidepressants.

Drinking exacerbates symptoms, so it should be avoided.

Vitamins and supplements are worth a try because they have low side effects risk.

Sedatives such as benzodiazepines worked, but additional research is needed because caution is needed for use it.

Fluorescent light or interior lighting were more likely to make symptoms worse than any outdoor environment.

Thank you for reading.

Please use the community for questions. ^^


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